Contents page of the issue Februar 2006




INFLUENZA

B. Lomniczi: History of influenza virus infections with reference to H5N1 avian influenza outbreaks in East Asia / 67

BOVINE
A. Répási, J.-F. Beckers, J. Sulon, J. Reiczigel, O. Szenci: Effect of prostaglandin treatment on corpus luteum, plasma progesteron concentration and on graafian follicle. Secondary communication / 82

PORCINE
T. Süveges: Severe skin changes associated to primary parakeratosis in sucking piglets / 86
Addition–Remark (J. Szabó) / 92

SMALL ANIMALS
P. Csébi, A. Arany-Tóth: Radiological and CT-examination of the nasal cavity and paranasal sinuses in small animals / 95
S. Wilhem, M. Löwenstein, U. Truyen: Detection of parvovirus antibody with fast-test in the small animal practice / 103
Forging ahead of endoscopy (editorial article) / 107

WILD ANIMALS
J. Juhász, G. Gere, S. Andrikovics: Aspergillus fumigatus infection of black-headed gulls (Larus ridibundus) / 109
Z. Zomborszky – Sz. Nagy: Development of the cryopreservation technique of red deer epididymal spermatozoa. Preliminary communication / 111

ZOONOSES
D. Ebrecht, E. Müller: Zoonoses in rabbits / 114

FOOD-HYGIENE
I. Barna-Vetró, E. Szabó, J. Schrett, Iné Szigeti, L. Sziráki, L. Solti: Fast determination of drug-residues in the milk with ELISA-test / 120

ALMA MATER
Diploma giving ceremony / 127

BOOK REVIEW
P. Prélaud, D Rosenberg, P. de Formel: Endocrinological diagnosis in the small animal practice / 128

B. Lomniczi:
HISTORY OF INFLUENZA VIRUS INFECTIONS WITH REFERENCE TO H5N1 AVIAN INFLUENZA OUTBREAKS IN EAST ASIA

Relationships of influenza viruses and their hosts are overviewed as a historical process. First, infection by harmless avian influenza viruses is presented including a great diversity of hosts (wild aquatic birds) and viruses (Figure 1). Ancient evolutionary processes, such as delineations according to primary hosts and/or geography as well as creation of novel gene combinations by reassortments leading to present diversity are described. Then infections in secondary host species (chicken, man, horse and swine) emerged during civilization are outlined that were initiated with colonisation by primitive viruses from the natural hosts, a process that is still continuing (Figure 2). Disease forms which had emerged in secondary hosts due to unnatural keeping of animals and change of virus properties are detailed. The influence of these factors on the genesis of epidemics is also treated. Namely, the transition from sporadic forms, that manifest in outbreaks caused by highly pathogenic strains due to local mutation of their low pathogenic version, to typical acute epidemic (Figure 3). Circumstances, including high density poultry populations, mixed keeping of land-based poultry and water-fowls as well as multiple ressortment of viruses in the region are discussed as major factors in eliciting the unprecedented territorial spread of the current H5N1 Asian epizootic and the emergence of duck pathogenic strains that contaminated the natural reservoir.

T. Süveges:
SEVERE SKIN CHANGES ASSOCIATED TO PRIMARY PARAKERATOSIS IN SUCKING PIGLETS

The author diagnosed parakeratosis in sucking piglets in many pig holdings. Diagnosis was confirmed by the typical macroscopic and histopathological changes, presented also on pictures (in cases without complications, non-inflammatory pathological keratinisation of the dermal epidermis, sometimes of the multilayered epithelium of the tongue, dilatation of perspiration glands – hyperhidrosis) and also excluded skin diseases considerable from the point of view of differential diagnosis.
He recommends for the prevention of the disease zinc supplementation of the feedstuffs of pregnant and milking sows and sucking piglets according to demand, and elimination of factors preventing zinc absorption and utilization including infections causing malabsorption.

P. Csébi – A. Arany-Tóth:
RADIOLOGICAL AND CT-EXAMINATION OF THE NASAL CAVITY AND PARANASAL SINUSES IN SMALL ANIMALS

The authors briefly present the anatomy of the nasal cavity and paranasal sinuses, and the process of radiological and CT-examinations. They give the radiograph and CT-image of the healthy region. From the frequent changes, they present in details the radiological image of tumours, aspergillosis, rhinitises of different origin and foreign body. They emphasise the importance of CT-examination in the differentiation between inflammatory and neoplastic processes.

J. Juhász – G. Gere – S. Andrikovics:
ASPERGILLUS FUMIGATUS INFECTION OF BLACK-HEADED GULLS (LARUS RIDIBUNDUS). CASE REPORT

The authors caught and kept under good hygienic conditions 29 1–12 days old black-headed gull nestlings, seemed to be healthy, for feeding and performance-biological experiments. After 3–4 days the animals showed dyspnoeic clinical signs with good appetite and after some days 80% of them died in spite of vitamin treatment. In the lung and on the air sacs tiny greenish-yellow loading were found from which Aspergillus fumigatus was cultured. In the collection area similar clinical signs and death of high proportion was observed among the wild gull. The infection was probably caused by the mouldy straw placed in the gulls’ living area for the purpose of weed control.

Z. Zomborszky – Sz. Nagy:
DEVELOPMENT OF THE CRYOPRESERVATION TECHNIQUE OF RED DEER EPIDIDYMAL SPERMATOZOA. PRELIMINARY COMMUNICATION

An improved red deer sperm processing protocol is discussed briefly. This protocol contains the steps of the collection, processing and cryopreservation of post mortem collected epididymal spermatozoa of hunted red deer stags. During the roaring season of 2004, epididymal sperm samples of five red deer stags were collected post mortem. Samples were processed in a commercial bovine semen extender, filled into 0.25 ml straws, then they were frozen by holding in liquid N2 vapor. Initial and post-thaw motility was assessed visually. Post-thaw motility was acceptable in case of every stag. This protocol will allow to build a red deer sperm bank by collecting and freezing spermatozoa of the stags hunted in Hungary.

I. Barna-Vetró – E. Szabó – J. Schrett – I. Szigeti – L. Sziráki – L. Solti:
FAST DETERMINATION OF DRUG-RESIDUES IN THE MILK WITH ELISA-TEST

The authors report about direct, competitive ELISA tests for determination of three drug residues (gentamicin, sulphamethazine, sulphadiazine) in milk samples based on monoclonal antibodies. The assays have been validated by the most important reliability data e.g. specificity, measuring range, detection limits (Table1, 2, 3 and 4 ) reproducibility (Table 5 and 6) as well as accuracy (Table 7,8 and 9).
The preparation of milk samples is simple as they are used directly, without any extraction, in the test. The quality parameters of the developed ELISA-tests meet all the EU-requirements related to the determination of 100 µg/kg residue in milk. Gentamicin: measuring range 0.1–10 ng/ml, detection limit of 0.03 ng/ml. Sulphamethazine: measuring range 25–1000 ng/ml, detection limit of 10 ng/ml. Sulphadiazine: measuring range 2,5–50 ng/ml, detection limit of 1.5 ng/ml.
Thus, the developed ELISA tests can be used both for preliminary screening and for quantitative determination of drug residues in milk.